Targeting post-translational modifications of Foxp3: a new paradigm for regulatory T cell-specific therapy
A healthy immune system is pivotal for the hosts to resist external pathogens and maintain homeostasis; however, the immunosuppressive tumor microenvironment (TME) damages the anti-tumor immunity and promotes tumor progression, invasion, and metastasis.Recently, many studies have found that Foxp3+ regulatory T (Treg) cells are the major immunosuppr